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pentobarbital will reduce the extent or effect of estradiol vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Watch Intently (one)pentobarbital will reduce the extent or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lack of, or reduced reaction to tofacitinib